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<i>Thujopsis dolabrata<_i> (Thunberg ex L. f.) Sieb. et Zucc.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Cannabinoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Integrin (1) NF-κB (2) p38 MAPK (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0263

Toosendanin 3 Publications Verification	Others	Inflammation/Immunology
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

HY-N2247

Guaiacin
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

HY-N6930

Shikonofuran A

Others Metabolic Disease

Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
HY-N11030

Futoamide

Others Others

Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC .
HY-N8919

N-trans-Sinapoyltyramine

Others Others

N-trans-Sinapoyltyramine is an alkaloid. N-trans-Sinapoyltyramine can be isolated from Lindera glauca Sieb Zucc .

Shikonofuran A	Others	Metabolic Disease
Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.

Futoamide	Others	Others
Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC .

N-trans-Sinapoyltyramine	Others	Others
N-trans-Sinapoyltyramine is an alkaloid. N-trans-Sinapoyltyramine can be isolated from Lindera glauca Sieb Zucc .

HY-N2394

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Others	Inflammation/Immunology
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM .

HY-122960

Epifriedelanol acetate	Cannabinoid Receptor	Others
Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb .

HY-N5112B

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	HIF/HIF Prolyl-Hydroxylase	Cancer
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity .

HY-N0631

Cornuside 1 Publications Verification	p38 MAPK NF-κB	Inflammation/Immunology
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases .

HY-107237

Broussonetine A

Others Others

Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .
HY-N8956

Pachysamine M

Others Others

Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .
HY-N7756

2-Deacetoxydecinnamoyltaxinine J

Others Others

2-Deacetoxydecinnamoyltaxinine J is an active compound that can be isolated from Taxus cuspidta Sibe et Zucc .

Broussonetine A	Others	Others
Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .

Pachysamine M	Others	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

2-Deacetoxydecinnamoyltaxinine J	Others	Others
2-Deacetoxydecinnamoyltaxinine J is an active compound that can be isolated from Taxus cuspidta Sibe et Zucc .

HY-N4164

Schinifoline	Apoptosis	Cancer
Schinifoline, a 4-quinolinone derivative isolated from Zanthoxylum schinifolium Sieb, improves radiosensitizing effect, and effects cell cycle and apoptotic-inducing effects in cancer .

HY-N8903

Mumefural	Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor	Cardiovascular Disease Neurological Disease
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Others	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

Toosendanin 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Melia toosendan Sieb. et Zucc. Plants Inflammation/Immunology Disease Research Fields Meliaceae	Others
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Quinones Classification of Application Fields Rheum palmatum L. Anthraquinones Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM .

Shikonofuran A	Natural Products Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Lithospermum canescens Lehm. Disease Research Fields Boraginaceae	Others
Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.

Futoamide	Structural Classification Simple Phenylpropanols Source classification Piper kadsura Piperaceae Phenylpropanoids Plants	Others
Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC .

N-trans-Sinapoyltyramine	Structural Classification Source classification Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume	Others
N-trans-Sinapoyltyramine is an alkaloid. N-trans-Sinapoyltyramine can be isolated from Lindera glauca Sieb Zucc .

Epifriedelanol acetate	Triterpenes Structural Classification Buxaceae Terpenoids Source classification Pachysandra terminalis Siebold & Zucc. Plants	Cannabinoid Receptor
Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb .

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	Quinones Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	HIF/HIF Prolyl-Hydroxylase
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity .

Cornuside 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	p38 MAPK NF-κB
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases .

Broussonetine A	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields	Others
Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .

Pachysamine M	Structural Classification Alkaloids Buxaceae Other Alkaloids Source classification Pachysandra terminalis Siebold & Zucc. Plants	Others
Pachysamine M (Compound 5) is a pregnane alkaloid. Pachysamine M is isolated from naturalPachysandra terminalisSieb. et Zucc .

2-Deacetoxydecinnamoyltaxinine J	Structural Classification Natural Products Source classification Taxaceae Plants Taxus wallichiana Zucc.	Others
2-Deacetoxydecinnamoyltaxinine J is an active compound that can be isolated from Taxus cuspidta Sibe et Zucc .

Schinifoline	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis
Schinifoline, a 4-quinolinone derivative isolated from Zanthoxylum schinifolium Sieb, improves radiosensitizing effect, and effects cell cycle and apoptotic-inducing effects in cancer .

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Typhaceae Source classification Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields	Others
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

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<i>Thujopsis dolabrata<_i> (Thunberg ex L. f.) Sieb. et Zucc.

Inhibitors & Agonists

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